Age-Related Changes of Cholinergic Markers in the Rat Brain

Age-related changes in the expression of ER-β mRNA in the female rat brain

Age-related changes in rat retina.

PURPOSE To describe the changes in rat retina occurring with ageing by means of histological methods, scanning electron microscopic observations and morphometrical data; and to study by means of biochemical methods the amount of protein content in retinal tissues. METHODS Samples of fresh retinal tissue obtained from young, adult, and aged rats were studied by means of traditional histologica...

Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain.

We have recently developed 1-([3-O-methyl-11C]3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine ([11C]SA4503) as a selective radioligand for mapping sigma1 receptors in the brain by positron emission tomography (PET). In the present short communication we evaluated the age-related changes of the binding of this ligand to sigma1 receptors in Fisher-344 rats (1.5-, 6-, 12-, and 24-month-old) ...

Age-related changes in sleep in the rat.

Human sleep in old age is characterized by a number of changes, including reductions in sleep efficiency, amounts of visually scored slow-wave and REM sleep, and amplitude of the diurnal sleep/wake rhythm. In older rats, some, but not all, of these traits have been reported, including a decrease in the mean duration of sleep bouts, an increase in the number of sleep bouts, and a modest reductio...

Age-related changes in auditory temporal processing in the rat.

Presbycusis, as the deterioration of hearing ability occurring with aging, can be manifested not only in a shift of hearing thresholds, but also in a deterioration of the temporal processing of acoustical signals, which may in elderly people result in degraded speech comprehension. In this study we assessed the age-related changes in the temporal processing of acoustical signals in the auditory...